GLP-1Novo Nordisk

Semaglutide

Semaglutide is a GLP-1 receptor agonist that helps regulate appetite and blood sugar. It's one of the most widely prescribed medications for weight loss, available as both a weekly injection and daily oral pill.

WegovyOzempicRybelsus

Brand-Name Cost

$1,000-1,400/month

Compounded Cost

$149-299/month

Type

GLP-1 Agonist

How Semaglutide Works

Semaglutide mimics the GLP-1 hormone, which is naturally released after eating. It slows gastric emptying, reduces appetite, and helps regulate blood sugar levels. This leads to reduced food intake and weight loss.

Effectiveness

Clinical trials show an average weight loss of 15-17% of body weight over 68 weeks. The STEP trials demonstrated significant improvements in cardiovascular risk factors as well.

Dosing

Weekly injection starting at 0.25mg, gradually increasing to maintenance dose of 2.4mg. Oral form (Rybelsus) is taken daily at 7mg or 14mg.

FDA-Approved Uses

Weight loss (Wegovy)
Type 2 diabetes (Ozempic, Rybelsus)

Common Side Effects

Nausea

Vomiting

Diarrhea

Constipation

Abdominal pain

Headache

Most side effects are mild and improve over time as your body adjusts to the medication.

Important Warnings

•Not for people with personal/family history of medullary thyroid carcinoma
•Not for people with Multiple Endocrine Neoplasia syndrome type 2
•Use caution with history of pancreatitis

Where to Get Semaglutide

Hims/Hers

From $199/mo

Henry Meds

From $149/mo

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